Principal Investigator: Joseph Connor, MD
Sara Fleming, ND, DFM Research Fellow

PI Department: Obstetrics and Gynecology

Summary of Study: The purpose of this study is to determine the effects of Indole-3-Carbinol (I-3-C) on estrogen metabolism in premenopausal women across a range of body mass index.

Objective: The goal of this project is to determine whether I-3-C raises estrogen metabolism in women with high body mass index. A secondary goal is to determine whether there is a differential response to I-3-C based on body mass index.

Study Design: The approved study action consists of posting recruitment flyers. The overall study involves recruitment of 40 participants ages 30-50, with no history of premature ovarian failure and no known allergies to I-3-C. The study involves 3 visits including laboratory urine collection. Each participant will be given capsular I-3-C to be taken twice daily for 8 weeks along with a medication diary to monitor observations and side effects.

DFM Clinic(s): Any DFM clinic wishing to participate. Approved for posting of recruitment flyers.

DFM Contact: Mary Beth Plane, PhD

Study Contact Person:
Sara Fleming, ND
Study Coordinator
608-235-1091
sara.fleming@fammed.wisc.edu

Date of Approval: September 2009

Dates of Study: 9/09 - 12/10