Principal Investigator: Giulio Tononi, MD, PhD

PI Department: Psychiatry

Project Study Title: Sleep Function and Synaptic Homeostasis: Linking Neurobiology and Mental Health

Summary of Study: This study proposes the use of high-resolution brain imaging techniques to investigate the brain systems regulating mood and sleep.

Objective: Study objectives consist of the following: 1) Characterize normal profiles of high density EEG activity during sleep; 2) Characterize local regulation of sleep using high-density EEG; 3) Investigate alterations in objective 1 and 2 associated with a large population of subjects with brain related conditions, including psychiatric disorders and primary sleep disorders, which affect plasticity and/or sleep patterns.

Study Design: This study involves 6 visits to the sleep laboratory: 1 daytime visit and 5 overnight stays. The day visit will involve an interview to determine if the participant meets study criteria. The 5 night visits involve the use of high-density EEG to selectively suppress slow wave sleep. Study participants will be paid for their time.

DFM Clinic(s): Any DFM clinics choosing to participate

DFM Contact: Mary Beth Plane, PhD

Study Contact Person:

Eric Landsness
Study Coordinator
263-6088
landsness@wisc.edu

Date of Approval: June 2009

Dates of Study: June 2009 - April 2010