Current WREN Research Projects

Principal Investigator:  Bruce Goldberg, MD – Oregon Health and Science University

Project Summary:  ACTION 4 Task Orders (RFTO) will focus on practical, applied topics of high interest to AHRQ and the Department of Health and Human Services as well as to those at the front lines of care delivery and to the patients they serve. RFTOs will be conceived with end users in mind (especially health systems and other care providers) and will be focused on topics that will benefit from being researched, developed, tested, evaluated, implemented and disseminated in field‐based/real world settings.

WREN is a member of Meta-LARC, a network of practice-based networks (PBRNs) working on this project.

Funding Agency:  Agency for Healthcare Research & Quality (AHRQ)

Principal Investigator:  Annette Totten, PhD – Oregon Health & Science University

Project Summary:  This project is designed to address the PCORI-identified need “for evidence to support adults with advanced illnesses and their caregivers in care planning over time so that care is consistent with their goals and preferences”.  This will be a cluster-randomized trial comparing team-based versus primary care clinician-focused advance care planning in practice-based research networks.

Funding Agency:  Patient-Centered Outcomes Research Institute (PCORI)

Principal Investigator:  Eric Simpson, MD, MCR – Oregon Health & Science University

Project Summary:  This is a pragmatic, multi-site, randomized community-based trial in which dyads of a parent or legal guardian (“parent”) and an infant age 0 to 2 months are enrolled to test the hypothesis that a skin care regimen utilizing emollient therapy from birth can prevent or delay onset of atopic dermatitis.

Funding Agency: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIH-NIAMS)

Principal Investigator: David Feldstein, MD UW SMPH – Department of General Internal Medicine

Project Summary: The overall objectives are to 1) implement registered nurse (RN)-driven clinical decision support (CDS)containing integrated clinical prediction rules (iCPRs) [decision aids embedded into the electronic health record which determine risk of bacterial infection based on elements of the patient history and physical examination] and 2) determine the impact of RN-driven CDS on inappropriate antibiotic prescribing and resource use.

Funding Agency: New York University School of Medicine

Principal Investigator: Ronald Aronson, MD  Bristol-Myers Squibb

Project Summary: Pragmatic study of approximately 52,000 with Asymptomatic Atrial Fibrillation.  An abnormal heart rhythm called atrial fibrillation (AF) can increase the risk of having a stroke if a blood clot forms and travels through the blood stream to the brain. The purpose of this study is to determine if screening patients with a device to detect abnormal heart rhythms reduces the risk of stroke compared to usual standard of care. Since abnormal heart rhythms can come and go, monitoring can increase the chance of detecting AF that is otherwise undiagnosed.

Funding Agency: Bristol-Myers Squibb

Principal Investigator:  Corrine Voils, PhD – UW SMPH, Dept of General Surgery

Project Summary:  This study will provide critical insight into the efficacy of systematically involving domestic partners to optimize long-term weight loss. Results from the mediation analyses will provide unique knowledge about the mechanisms underlying a couples’-based approach for patient weight management. As such, the results will inform future intervention refinements to optimize patient outcomes and scalability. Completion of this study will contribute to our long-term goal of identifying and implementing efficacious, cost-effective approaches to reduce obesity and associated outcomes.

Funding Agency:  National Institutes of Health (R01)

Principal Investigator: Andrew Quanbeck, PhD, UW SMPH – Department of Family Medicine and Community Health

Project Summary: The goal of the proposed project is to determine which combination of strategies—physician-led audit and feedback, organizational facilitation, and physician-to-physician peer coaching—works most effectively in different clinics, based on an assessment of their organizational needs. It may be that in some clinics, audit and feedback alone suffices for improvement. If more intensive help is required, facilitation and/or physician-to-physician peer coaching can be added.

Funding Agency: National Institutes of Health (NIH)

Principal Investigator: Ellen Goldstein, PhD, UW SMPH – Department of Family Medicine and Community Health

Project Summary: The first few years of life are a period of exponential brain growth and development. The effects of early exposure to opioids on infant and child development are unknown.  To address this knowledge gap, NIH is supporting research to better understand typical brain development, beginning in the prenatal period and extending through early childhood, including variability in development and how it contributes to cognitive, behavioral, social, and emotional function. Knowledge of normative brain trajectories is critical to understanding how brain development may be affected by exposure to opioids and other substances (e.g., alcohol, tobacco, cannabis), stressors, trauma, and other significant environmental influences, including those that promote resilience.

Funding Agency: National Institute of Health

Principal Investigator: Bruce Barrett, MD, PhD, UW SMPH – Department of Family Medicine and Community Health

Project Summary:  A Comparative Effectiveness Randomized Controlled Trial of Mindfulness Meditation versus Cognitive Behavioral Therapy for Opioid-Treated Chronic Low Back Pain

This randomized, controlled trial will test the relative benefit of Mindfulness Meditation (MM) vs. Cognitive Behavioral Therapy (CBT) in improving outcomes for patients with chronic low-back pain treated with opioids.

Funding Agency:  Patient-Centered Outcomes Research Institute (PCORI)

Meta-Network Affiliations

Project Summary: Creation of research and learning consortium of 6 PBRNs: Oregon, Colorado, Wisconsin, Iowa, and Quebec to accelerate the conduct of PBRN research through a common infrastructure enabling the efficient conduct of research. The consortium will promote continuous learning across networks and practices for evidence dissemination and knowledge transfer.

Funding Agency: Agency for Healthcare Research and Quality

Workshop: Multi-Network Research Collaboration: Steps to Success

Wisconsin Research & Education Network (WREN)

Just Published!

The Burden of Childhood Atopic Dermatitis in the Primary Care Setting:  A Report from the Meta-LARC Consortium

This article is a result of Eric Simpson’s pilot study, Community-based Assessment of Skin Care, Allergies and Eczema (CASCADE).

Identification of Barriers, Facilitators and System-Based Implementation Strategies to Increase Teleophthalmology Use for Diabetic Eye Screening in a Rural US Primary Care Clinic: A Qualitative Study

This article captures the real-world perspectives of patients and providers in using teleophthalmology to address diabetic eye screening. Dr. Liu’s NIH-funded study is one of the first to address implementation strategies suggested by both patients and primary care providers.

Congratulations Authors!